Inophos 400 Tablet 20pcs

Uses of Inophos 400

• High phosphate levels in blood

Side Effects of Inophos 400

• Common: Dyspepsia, peritonitis, diarrhea, nausea, constipation, pruritus, abdominal distension, vomiting, fatigue, anorexia, arthralgia.
• Less common: Ileus, bowel obstruction, bowel perforation.

How does Inophos 400 work?

Inophos 400 binds to phosphate in the gut, preventing its absorption and thus lowering serum phosphate levels without affecting calcium, aluminum, or bicarbonate levels.

Quick Suggestions:

• If a dose is missed, skip it and return to your normal schedule. Do not double the dose.
• Always take Inophos 400 with food.
• Follow your doctor's dietary recommendations.
• Monitor for and report any new symptoms or side effects to your healthcare provider.

Indications:

Inophos 400 mg is indicated for the reduction of serum phosphorus in patients with end-stage renal disease (ESRD).

Pharmacology

Inophos is used for controlling serum phosphorus levels in patients with chronic kidney disease (CKD) undergoing dialysis. It helps prevent complications related to elevated phosphorus levels, such as secondary hyperparathyroidism, renal bone disease, vascular calcification, and cardiovascular disease. It is a calcium-free, aluminum-free nonabsorbed polymer phosphate binder that works by inhibiting intestinal phosphate absorption when taken with meals.

Dosage & Administration:

For patients not taking a phosphate binder:

• Serum Phosphorus >5.5 and <7.5 mg/dL: 800 mg (2 tablets) three times daily with meals.
• Serum Phosphorus ≥7.5 and <9.0 mg/dL: 1200 mg (3 tablets) three times daily with meals.
• Serum Phosphorus ≥9.0 mg/dL: 1600 mg (4 tablets) three times daily with meals.

For patients switching from calcium acetate to Sevelamer:

• Calcium Acetate 667 mg (1 tablet): Sevelamer 800 mg (2 tablets).
• Calcium Acetate 1334 mg (2 tablets): Sevelamer 1200 mg (3 tablets).
• Calcium Acetate 2001 mg (3 tablets): Sevelamer 2000 mg (5 tablets).

Dose Titration:

• Increase by 400 mg (1 tablet) per meal if serum phosphorus >5.5 mg/dL at 2-week intervals.
• Maintain current dose if serum phosphorus is 3.5-5.5 mg/dL.
• Decrease by 400 mg (1 tablet) per meal if serum phosphorus <3.5 mg/dL.

Take it with food. Swallow whole; do not chew, crush, or break.

Interaction

Studied with ciprofloxacin, digoxin, warfarin, enalapril, metoprolol, and iron.

Contraindications

Hypophosphatemia, bowel obstruction, hypersensitivity to Sevelamer hydrochloride or any of its constituents.

Pregnancy & Lactation

• Pregnancy Category C: Use during pregnancy only if the potential benefit justifies the risk.
• No adequate studies on breastfeeding mothers; use only if the benefit outweighs the risks.

Precautions & Warnings

Safety is not established in patients with dysphagia, swallowing disorders, severe GI motility disorders, or major GI tract surgery. Use with caution in these conditions.

Storage:

Store in a dry cool place